highly significantP = 4.008 × 10 −6
Likewise, COX2 dimer (the 2nd largest protein in our set, with N = 1,104) exhibited a highly significant overlap ( P = 4.008 × 10 −6 ) with m = 18; and PA (the 4th largest; N = 763, m = 10) also yielded a P -value of the order of 10 −6 .