Anhedonia is associated with a specific depression profile and poor antidepressant response.

Although the relationship between MDD and thyroid diseases is well-established, 37 , 38 the specific relationship between anhedonia and thyroid function still needs to be clarified, as only one study reported a nonsignificant trend toward higher TSH level in subjects with anhedonia compared to those without. 39 More compelling is the emerging evidence highlighting the impact of insulin resistance, which is a hallmark of diabetes mellitus type 2, on brain function, particularly in regions integral to mood regulation and reward

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