Adenosine A2B receptor activation regulates the balance between T helper 17 cells and regulatory T cells, and inhibits regulatory T cells exhaustion in experimental autoimmune myositis.

The adenosine A2B receptor agonist inhibits CD4 + T‐cell exhaustion As shown in the heat map (Figure 3A ), an increasing trend in the expression of T‐cell exhaustion‐related genes was observed in the skeletal muscles of EAM mice compared with controls.

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