Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch.

In HCT116 xenograft mice, compared with in the control group, an increasing trend in ROS production was observed in NCI-006- and IACS-010759-treated groups, and a significant increase was observed in the combination-treated group (p < 0.05, Fig 3B ).

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