Mesenchymal Stem Cells and Their Derived Exosomes Mitigated Hepatic Cirrhosis in Rats by Altering the Expression of miR-23b and miR-221.

Effect of Administration of hUCB-MSCs and/or their Derived Exosomes on the Expression of miRNA and Autophagy and Fibrotic Pathways Compared with the control rats, the cirrhotic rats showed a highly significant upregulation in the expression of miRNA-221 (1.00±0.09 versus 4.20±0.51), TGF-β1 (1.01±0.12 versus 3.98±0.78), MMP9 (1.01±0.15 versus 6.59±0.79), fibronectin (1.02±0.19 versus 8.15±0.82), collagen I (1.01±0.17 versus 6.94±0.65), α-SMA (1.02±0.18 versus 7.68±0.66), Smad2 (1.01±0.14 versus 12.93±0.85), and P62 (1.01±0.17 versus 6.61±0.91) (P<0.001, for each).

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