Sex hormone deficiency in male and female mice expressing the Alzheimer's disease-associated risk-factor TREM2 R47H variant impacts the musculoskeletal system in a sex- and genotype-dependent manner.

On the other hand, the only measurements that showed surgery × genotype interactions were post-yield work, and toughness, with tendencies toward significance in total work and yield stress for males, and significant difference in ultimate force and a tendency toward significance for ultimate stress for females ( Table S2 ).

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