A three-phase strategy of bionic drug reservoir scaffold by 3D printing and layer-by-layer modification for chronic relapse management in traumatic osteomyelitis.

Consequently, the pH of the composite system is on an increasing trend, creating a weakly alkaline environment that is conducive to osteogenesis and bacterial clearance [ 41 ]. 3.2.

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S9 ).It was shown that the highest bacterial killing rate of 98.33 ± 0.6 % was observed in the Composite scaffold (C-120 h) group at 120 min of bacterial inoculation, and there was a decreasing trend of intracellular bacterial killing in the scaffold group after C-360 h, which was correlated with the decrease in the release of AMPs.

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