The data provided herein indicate that this FXR-dependent ( Fig 1B ) upregulation of Bsep gene expression in response to CDCA can be almost significantly inhibited by concentrations of as low as 0.1 ng/ml IL-1β or for TNF-α 0.5 ng/ml in murine PMH and 1 ng/ml in HepaRG cells ( Fig 2 ).
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Interleukin 1 β suppresses bile acid-induced BSEP expression via a CXCR2-dependent feedback mechanism.
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