Antiangiogenic therapy exerts antitumor effects by altering the tumor microenvironment: bibliometric analysis.

This analysis further indicates a pronounced trend in research evolution, characterized by a transition from examining individual angiogenic factors to embracing an integrated approach that leverages multi-target signaling pathways.

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The co-citation network is obtained by clustering operation on the basis of the cited articles, and using the latent semantic indexing (LSI) algorithm to extract noun terms from the keywords, which are divided into 13 clusters, with a clustering module value of 0.844, and a cluster mean contour value of 0.962, and S > 0.1 indicates a highly significant clustering structure and a convincing clustering effect.

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