Characterization of medical device randomized controlled trials with adaptive designs.

Discussion A decreasing trend of using adaptive design in medical device RCTs We identified 105 medical devices RCTs with adaptive designs, accounting for 2.112 adaptive RCTs in every 1000 (105/49,721) medical device clinical trials registered in the ClinicalTrials.gov database for the past two decades (from 2000 to 2024).

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