Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development.

Since the mechanical studies in STAT3-OKO-M mice all yielded highly significant effects (p<0.005), while the studies in STAT3-OKO-BL, despite similar effect sizes, did not achieve the 0.025 threshold, we sought to further confirm our prediction of defects in intrinsic parameters consistent with altered bone quality by determining whether meta-analysis of the combined studies yielded significant effects.

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Significant male-specific increase in osteoid was detected in all cases, except that the increase in OV/BV for STAT3-OKO-BL did not achieve significance (p = 0.08).

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