Zhuanggu Shubi ointment mediated the characteristic bacteria-intestinal mucosal barrier-bone metabolism axis to intervene in postmenopausal osteoporosis.

3.2 Effects of ZGSBG on femoral density, structure and bone metabolism in PMO rats 3.2.1 ZGSBG enhanced the bone density in PMO rats Compared with the Sham group, Tb.BV/TV, Tb.BMD, Tb.Th, and Tb.N in the OVX group significantly decreased ( P <0.05; P <0.05; P <0.05; P <0.05), however, Tb.Sp showed an increasing trend ( P >0.05).

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Compared with the OVX group, Tb.BMD, Tb.BV/TV, Tb.Th, and Tb.N in the ZGSBG group increased ( P >0.05; P <0.05; P <0.05; P <0.05) but Tb.Sp showed a decreasing trend ( P >0.05) ( Table 4 , Figure 2A ).

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