Sex-Dependent Effects of CYP2D6 on the Pharmacokinetics of Berberine in Humans.

Clin Pharmacol Ther · 2025 · PMC11652804 · PMID 39488825

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highly significantno p-value reported

Despite the small number of participants, we observed a highly significant increase in metabolite‐to‐berberine ratios in urine for the phase I metabolite M2 and the resulting phase II metabolites M8 and M9 ( Figure S4 ).

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