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Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway.

BMC Gastroenterol · 2024 · PMC11653842 · PMID 39695403

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an increasing trendno p-value reported
With the continuous improvement of people’s living standards and changes in lifestyle, the incidence of UC has shown an increasing trend year by year [ 31 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.