Intratumoural expression of dihydropyrimidine dehydrogenase is an independent prognostic factor in resected pancreatic ductal adenocarcinoma treated with adjuvant gemcitabine.

In the Gem treated group of patients, TNM stage and DPD expression levels were both independent parameters for survival (with P=0.018 and P=0.036, respectively), whereas sex was borderline significant (P=0.050, Table III ).

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Historically, the outcome for patients with PDAC has been poor with almost no long-time survivors, yet recent data indicate a positive trend with 10-year survival (all stages combined) now climbing towards 10% ( 2 ).

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