highly significantp < 0.0001
In a similar association analysis including all three SNPs as a triple haplotype (rs1801260/rs34789226/rs6486121), the global haplotypic differences were highly significant ( p < 0.0001), with C/T/C, C/T/T, and C/C/T/T haplotypes being more frequent in cases than in controls, and T/C/C, T/C/T, and T/T/T being more frequent in controls than in cases (Table 3 ).