Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress.

Treatment of WT U-2 OS cells with arsenite showed a highly significant and global shortening of RNA upon stress (Mann–Whitney, p-value<10 –307 ) in stark contrast to ΔΔG3BP1/2 cells that showed substantially less shortening (Mann–Whitney, p-value<10 –5 ) ( Figure 6e , Figure 6—figure supplement 1g and h ).

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Additional analysis of data has showed that in fact, in unstressed cells, XRN1 KD leads to modestly significant reduction in overall transcript length (Fig. 3b, c).

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