If we examine acetyl-CoA synthesis in the donor LV vs RV, the up-regulation of pyruvate dehydrogenases (PDHA1, PDHB) and lactate dehydrogenase B (LDHB), and the highly significant (FDR ≤ 0.001) up-regulation of dihydrolipoamide dehydrogenase (DLD) and dihydrolipoamide acetyltransferase (DLAT) indicates there may be up-regulation of acetyl-CoA synthesis via lactate and pyruvate metabolism, which has been suggested previously in healthy adults 50 .
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Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies.
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