Transcriptomics of long-term, low oxygen storage coupled with ethylene signaling interference suggests neofunctionalization of hypoxia response pathways in apple (<i>Malus domestica</i>).

Functional enrichment of the 606 putative hypoxia genes revealed highly significant functional groups ( p < .00005) related to oxygen sensing and hypoxia (GO:0036293, GO:0070482, GO:0001666, GO:1901700) and energy management (GO:0015979, GO:0019684, GO:0009765, GO:0009055, and GO:0004022).

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At least 400 DE “n‐degron” genes at each time point were observed during the 9‐month storage period and showed a decreasing trend over time (Figure 2 ; Table S5 ).

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