Genetic and Genomic Approaches to the Study of Drug-Induced Liver Injury.

A larger study involving several causative drugs found a trend towards significance for the class I serotype HLA‐A11 in DILI associated with tricyclic antidepressants and diclofenac and for the class II serotype HLA‐DR6 with DILI due to chlorpromazine [ 22 ].

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This study reported a highly significant association with the HLA class I allele B*57:01 with 84% of cases carrying the risk allele; this was replicated in a smaller group of additional cases [ 6 ].

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