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TIGIT<sup>+</sup> CD4<sup>+</sup> regulatory T cells enhance PD-1 expression on CD8<sup>+</sup> T cells and promote tumor growth in a murine ovarian cancer model.

J Ovarian Res · 2024 · PMC11660701 · PMID 39707532

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a decreasing trendp < 0.0001actually significant
Our observations unveiled a clear correlation between the accumulation of TIGIT + Foxp3 + Tregs and the growth of ovarian cancer tumors (r 2 = 0.9258, p < 0.0001), while the levels of TIGIT − Foxp3 + Tregs displayed a decreasing trend in parallel (r 2 = 0.9258, p < 0.0001) (see Fig. 3 A).

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