Optogenetic inhibition of the locus coeruleus blocks vagus nerve stimulation-induced enhancement of extinction of conditioned fear in rats.

An unpaired t -test indicated a nonsignificant trend [ t (21) = 1.79, P = 0.087], suggesting that the effects of LC inhibition on learned associations may be attributed to alterations in anxiety or activity during extinction training, rather than blocking a critical pathway for VNS effects.

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