Impact on fluid balance of an optimized restrictive strategy targeting non-resuscitative fluids in intensive care patients with septic shock: a single-blind, multicenter, randomized, controlled, pilot study.

Although our pilot study did not achieve significance, considering the non-significant trend in fluid balance reduction in the optimized group (Fig. 2 B), our approach to limiting fluid overload remains worth exploring in a larger randomized controlled trial, perhaps in addition to other strategies such as early vasopressor use in the first 24 h of shock [ 10 ], limiting intravenous fluids in the absence of signs of severe hypoperfusion [ 11 ], and systematic use of diuretics [ 19 ].

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