an increasing trendP < 0.001
Similarly, there was an increasing trend in the total PQ base dosage administered (242.6 ± 79.7 vs. 265.7 ± 92.3 mg, P < 0.001), despite no significant differences in total weight-based PQ base dosage administered (3.38 ± 1.1 vs. 3.64 ± 1.3 mg/kg, P = 0.256) or the proportion of patients in the underdosing group (< 3.5 mg/kg; 296 [73.6%] vs. 167 [68.2%], P = 0.135] between the two periods.