Enrichment for clinical trials of early AD: Combining genetic risk factors and plasma p-tau as screening instruments.

Longitudinal cognitive changes Among CN, we observed significant time‐by‐group (G–T– and G–T+) interaction on longitudinal MMSE change (time x group G–T–: β = 0.282, p < 0.001; time × group G–T+: β = 0.240, p = 0.012), and a marginally significant interaction of time‐by‐group G+T– on MMSE after the multiple comparison correction (time × group G+T–: β = 0.220, p = 0.015) (Figure 1A ).

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