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Global, Regional, and National Burden of Cardiovascular Disease, 1990-2021: Results From the 2021 Global Burden of Disease Study.

Cureus · 2024 · PMC11668263 · PMID 39720386

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a decreasing trendno p-value reported
From 1990 to 2021, the ASIR of CVD showed a decreasing trend globally, except in Central Asia and East Asia.

also in 47,180 other papers

an increasing trendno p-value reported
It is worth noting that, globally, only Southern Sub-Saharan Africa has shown an increasing trend in CVD deaths over the past 30 years.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.