Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells.

Indeed, we demonstrated that intracerebellar treatment with Cxcl3 promotes migration and differentiation of pGCPs in 3‐month‐old Ptch1 +/− /Tis21 −/− mice, with a highly significant reduction of MB lesions extent, confirming the role of Cxcl3 as a MB suppressor also at a later stage of tumor development.

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