Intensity of Intrathecal Total IgG Synthesis in Multiple Sclerosis Correlates with the Degree of Pleocytosis, Diversity of Intrathecal Antiviral Antibody Specificities, and Female Sex.

We observed a highly significant correlation between mean IgG IF and the amount of M-CAI (Spearman’s ρ = 0.417, p < 0.001), R-CAI (Spearman’s ρ = 0.484, p < 0.001), and Z-CAI (Spearman’s ρ = 0.562, p < 0.001) as well as the frequency of single virus-CAI positivity ( Table 2 , Figure 1 , Supplementary Tables S2 and S5 ). 3.3.

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