In this study, the abnormally large testes were maintained in Fmr1-KO mice treated with Apocynin, and these FXS phenotypic characteristics were not reversed, although a statistical trend was observed towards a reduction in size with the higher administered dose of 30 mg/kg/day.
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Apocynin, a Selective NADPH Oxidase (Nox2) Inhibitor, Ameliorates Behavioural and Learning Deficits in the Fragile X Syndrome Mouse Model.
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