Immune-Inflammatory Response in Lifespan-What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study.

However, considering SIRI, simple linear regression shows a highly significant statistical correlation of this index with age, with an increase in SIRI values according to age ( Figure 2 a; R 2 = 0.08; p -value <0.0001), although significant heterogeneity exists at extreme ages ( Figure S5 ).

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