This is reflected in the ALPS index, which shows a decreasing trend as the disease progresses, reaching its lowest levels in AD. 25 The animal model of AD revealed the relationship between AD pathology and glymphatic circulation disorders.
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Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease.
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