PCNA and Rnh1 independently participate in the protection of mitochondrial genome against UV-induced mutagenesis in yeast cells.

Although there was no significant difference between the strains in the accumulation of mitochondrial point mutations in untreated cultures, upon irradiation, even at the lowest UV dose of 5 J/m 2 pol30-K164R cultures exhibited a highly significant ( p < 0.0001) increase of mitochondrial point mutations in relation to their POL30 + counterparts at the same dose (Fig. 3 c).

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