Furthermore, ELISA results showed that IL-10, VEGF-A and IL-6 secreted by macrophages were significantly increased after stimulation with PANC-1 TCM and exhibited a decreasing trend when using sh-METTL3 macrophages or reducing intracellular lactate levels (Fig. 4 B).
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Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer.
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