On day12, collagen deposition in the JHA group no longer increased and showed a decreasing trend which prevent excessive inflammation for reducing scarring, while the POF-only group and Iodoform group showed continuous increase, indicating that inflammation delayed the healing time, stimulated scar formation, and slowed down the wound repair process.
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Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas.
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