Assessing immunotherapy response: going beyond RECIST by integrating early tumor growth kinetics.

GR demonstrated a highly significant association (p < 0.001) with the time-to-event outcome, suggesting that higher GR values are associated with a shorter time to response, with a hazard ratio of 0.575 (95% CI: 0.489 - 0.677), indicating a 42.5% reduction in the hazard rate per unit increase.

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The parameter B was negatively associated with PFS, with a coefficient of -0.26 and a hazard ratio of 0.773, although the p-value was borderline significant (p< 0.05).

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A marginally significant association (p < 0.05) was observed for A, with one-unit increase in A being associated with a 30.4% reduction in the hazard rate, assuming a Weibull distribution. suggesting that higher A values are also associated with a shorter time to response.

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