Association between HPV vaccination and cervical screening policy changes and cervical cancer incidence and grade-3 cervical intraepithelial neoplasia incidence in England, 2006-2020: a population-based trends analysis.

When we looked at age-specific trends in women born from September 1989 (i.e., the birth cohorts who had been offered the HPV vaccine and the most recent pre-vaccination cohort), we found highly significant negative slopes for both invasive cervical cancer and CIN3 across all age group with rates falling between 17.4% and 28.0% per year (unconstrained model in Table 3 ).

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