marginally significantP = 0.058
At a concentration of 40 μM of compound 121 (comparable to 500 μg/mL of the extract), there was only a marginally significant inhibition of NO production (20%, P = 0.058). 86 This study explored the effect of multiple doses of the extract and isolated 121 on NO levels in an inflammatory model; however, the study was only conducted at the in vitro level.