KYN/TRP ratio presents as a more robust biomarker, showing a decreasing trend in our experimental results, reflecting the fact that AMI may lead to a reduction in tryptophan metabolites through the TLR4/Myd88 pathway.
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Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer.
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