Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction.

Cell Death Dis · 2025 · PMC11698980 · PMID 39753531

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0.0590

closest p · 1.2× alpha

0.0880

boldest claim

The sentences

a decreasing trendp = 0.059so close (0.05 < p ≤ 0.1)

We observed a significant increase of VEGFA ( p = 0.016) and a decreasing trend for KDR ( p = 0.059) in shERCC1 cells compared to NTCs (Fig. 2a ).

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a positive trendp = 0.075so close (0.05 < p ≤ 0.1)

We observed an increase of Kdr ( p = 0.026), platelet-derived growth factor receptor beta ( Pdgfrb) ( p = 0.030), angiopoietin2 ( Angpt2 ) ( p = 0.001) and a positive trend for Cd31 ( p = 0.075) in EC-KO mice compared to WT (Fig. 4a ) .

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an increasing trendp = 0.088so close (0.05 < p ≤ 0.1)

The capillary density (area of αSMA-, PDGFRβ+ vessels/total area) in the WM of EC-KO mice showed an increasing trend ( p = 0.088), while overall vascular density and arterial density (area of αSMA+, PDGFRβ+ vessels/total area) did not change between EC-KO in WT in all three brain regions (Fig. 4d , Supplementary Fig. 3c ).

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