Notably, the ameboid morphology of IL-1β-treated C20 cells was also associated to a highly significant enlargement of the cell body, measured as area covered by the cells (Fig. 1 B), and higher propensity of the resulting microglia to β-amyloid peptide engulfment compared to control (Fig. 1 C-D).
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18 kDa TSPO targeting drives polarized human microglia towards a protective and restorative neurosteroidome profile.
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