We found that the combination displayed a highly significant synergistic response in vivo against strain HNS1-2 (MIC TGC = 8 μg/mL, MIC APR = 4 μg/mL) carrying tet (X3), while tigecycline monotherapy failed to produce antibacterial outcomes.
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Overcoming <i>tet</i>(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.
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