Evaluation of the effectiveness of medroxyprogesterone on blood gases and short-term hospital outcomes in patients with chronic obstructive pulmonary disease treating with noninvasive ventilation: A randomized clinical trial.

Based on this study, the blood pH, and PCO2 improved in both groups significantly; however, the administration of medroxyprogesterone had no significant effects on O2 saturation and clinical outcomes, but acetazolamide was found to be more effective on blood gases in short-term treatment.[ 19 ] Another study also assessed the effects of medroxyprogesterone in this regard on 48 patients and reported that adding medroxyprogesterone to the management led to partial improvements in blood pH, but these effects were completely significant when combined with almitrine 50 mg bid.

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