Insights into the progressive impact of high-fat-diet induced insulin resistance on skeletal muscle and myocardium: A comprehensive study on C57BL6 mice.

As the time of feeding high fat feed prolonged, the P-FOXO1/FOXO1 ratio in the skeletal muscle ( Fig 8A and 8F ) and myocardium ( Fig 8I, 8N and S1 Raw images ) of HFD group mice showed a decreasing trend.

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Compared with the HFD-10 group, both PGC-1α and SIRT1 in the myocardium of the HFD-12 group showed an increasing trend, but there was no statistically significant difference (p>0.05) ( Fig 10C and 10D ).

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