Among the metabolites that showed an increasing trend in IVDD patients, SM(d16_1 SM(d16_1_24_1(15Z))), SM(d17_1_24_1(15Z)), SM(d18_1_16_0), SM(d18_1_24_1(15Z)), and stearoyl sphingomyelin all belong to sphingolipids, and sphingolipids are lipids with a special structure called “sphingolipid base.” Sphingolipids are lipids with a special structure called “sphingolipid base,” and sphingolipids are not only essential membrane components but also bioactive lipid mediators that regulate many biological functions [ 34 ].
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Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics.
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A total of 2‐methyl‐1,3‐cyclohexadiene, 3‐amino‐2‐piperidone, ethyl butyrate, glycyrrhetinic acid, SM(d16:1/24:1), SM(d17:1/24:1), SM(d18:1/16:0), SM(d18:1/24:1), stearoyl sphingomyelin and other metabolites are on the rise in patients with IVDD, methylcysteine, L‐methionine, cis, cis‐muconic acid, estrone, glycine, hydroxyoctanoic acid, methyl methanethiosulfonate, m‐methylhippuric acid, and vinylacetylglycine metabolites showed a decreasing trend, which was suggested by KEGG analysis to be related with glycine, serine and threonine metabolism, cyanoamino acid metabolism, citrate cycle (TCA cycle), aminoacyl‐tRNA biosynthesis, methane metabolism.