Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals.

Importantly, rAd5-SARS2-S1 immunized mice showed markedly significant levels of pulmonary IFN-γ + , TNF-α + , and IL-2 + TEM ( Fig. 5d ) and TCM ( Fig. 5e ) CD8 + T cells as well as TNF-α + memory CD4 + T cells ( Fig. 5f ).

also in 476 other papers