Alzheimer’s disease APOE neuropathology‐based score, amyloid, and ptau polygenic scores’ association with amyloid PET positivity

The amyloid‐PGS was also significantly associated with A+ (OR = 0.492, P = 0.026), whereas the ptau‐PGS did not quite reach significance (OR = 3.218, P = 0.054).

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The significant association between amyloid‐PGS and A+, and near significance after adding the APOE score, demonstrates the existence of additional genetic effects outside of APOE that have an impact on amyloid accumulation.

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