Barely Significant
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The paradigm of stem cell secretome in tissue repair and regeneration: Present and future perspectives.

Wound Repair Regen · 2025 · PMC11711308 · PMID 39780313

Europe PMCDOI
3
hedged sentences
0.0001
closest p · 0.0× alpha
0.0001
boldest claim

The sentences

highly significantp < 0.0001actually significant
A highly significant reduction in the levels of TNF‐α was also noted at Day 3 ( p < 0.0001) for the hGFs secretome group in comparison to the control groups.

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a positive trendno p-value reported
In vitro results indicated that the EV treatment produced a significant 2‐fold increase in the proportion of mNVCM entering the M phase ( p < 0.05) whilst there was a positive trend increase for mNVCM re‐entering the cell cycle for the CM treatment in comparison to the controls.

also in 11,005 other papers

a decreasing trendno p-value reported
an increasing trendno p-value reported
Moreover, the levels of αSMA and pro‐inflammatory IL‐4 expression indicated a decreasing trend whilst MMP‐2 expression in the pulmonary tissue indicated an increasing trend for LSC‐derived secretome in comparison to the PBS control.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.