Promising results have been reported particularly against Gram-positive bacteria (monoderms), 25 with encouraging MIC values and a positive trend even in the disruption of biofilm mass and in the fight against persister cells. 26 On the other hand, AF appears less effective against Gram-negative bacteria (diderms), likely because of its difficulties in penetrating the outer membrane of the double layer. 25 To address the issue of reduced drug efficacy, promising alternatives in the field of metal-based drugs are emerging as viable solutions to further improve the efficacy of antimicrobial treatments.
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Metal compounds as antimicrobial agents: 'smart' approaches for discovering new effective treatments.
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