Nonlinear Stress-Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone-Cartilage Unit.

To quantitatively test whether these spatial‐ and load‐induced variations in ECM nanostructure are significant, generalized additive models (GAMs) were also used to model the variation, and the results showed highly significant ( p < 0.001) differences with both anatomical location and loading state (Table S2 , Supporting Information).

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