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Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells.

World J Diabetes · 2025 · PMC11718479 · PMID 39959267

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After 24 h exposure of tacrolimus, the change in GP activity failed to achieve significance and there was no change in its expression.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.